Peritoneal metastases from colorectal cancer confer the worst survival among all metastatic sites. Hyperthermic intraperitoneal chemotherapy could be an effective method of adjuvant treatment of gc with a high risk of intraperitoneal progression. First explored in ovarian malignancies in the 1980s, hyperthermic intraperitoneal chemotherapy hipec in conjunction with cytoreductive surgery crs has become central in controlling peritoneal disease. Laparoscopic hyperthermic intraperitoneal chemotherapy.
Hyperthermic intraperitoneal chemotherapy hipec, also referred to as intraperitoneal hyperthermic chemotherapy iphc, has been proposed as an alternative for the treatment of cancers within the peritoneal cavity, including primary peritoneal mesothelioma and gastric cancer. Dietrich 1, 1 division of gynecologic oncology, university of kentucky, lexington, ky 40502, usa. Hyperthermic intraoperative peritoneal chemotherapy hipec is also done for other cancers that have spread to the peritoneal surfaces of the abdomen after cytoreduction debulking surgery is completed, such as ovarian, colon, gastric and pancreatic cancers. Despite the positive clinical achievement, a higher rate of adverse events and the frequency of discontinuity hampered the adoption of ip chemotherapy. Chemotherapy can be administered orally, systemically i. Pdf hyperthermic intraperitoneal chemotherapy hipec in. In this procedure, warmed anticancer drugs are infused and circulated in the peritoneal cavity abdomen for a short period of time. Currently, no treatment is established standard of care due to limited efficacy or considerable toxicity. Hipec cooperative program md anderson cancer center. Also known as hot chemotherapy, hipec is performed after the surgeon removes tumors or lesions from the abdominal area. Many different drug combinations and hipec regimens including bidirectional, i. Immediately after removing visible tumors through whats.
Hyperthermic or heated intraperitoneal chemoperfusion hipec is a surgical procedure thats giving new hope to patients with abdominal cancers. Immediately after removing visible tumors through whats called cytoreductive surgery, our surgeons pump a powerful dose of heated chemotherapy inside a patients abdomen. Unlike systemic chemotherapy delivery, which circulates throughout the body via the bloodstream, hipec delivers chemotherapy directly to cancer cells in the abdomen. Hyperthermic intraperitoneal chemotherapy hipec effective. Original article from the new england journal of medicine hyperthermic intraperitoneal chemotherapy in ovarian cancer. Chi, in early diagnosis and treatment of cancer series. An interesting treatment modality being investigated in the setting of recurrent ovarian carcinoma limited to the peritoneal cavity is hyperthermic intraperitoneal chemotherapy iphc or hipec. The chemotherapy is heated because this allows us to have additional tumor killing effects of chemotherapy and thats the reason we refer to it as hyperthermic intraperitoneal chemotherapy. Cytoreduction hyperthermic intraperitoneal chemotherapy surgery is a surgical procedure where we take the patient to the.
Cytoreductive surgery and hyperthermic intraperitoneal. Apr 17, 2019 previous studies about the prognostic value of the hipec have yielded controversial results. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for malignant peritoneal mesothelioma. Feb 15, 2010 hyperthermic intraperitoneal chemotherapy hipec delivered in the operating room once the cytoreductive surgical procedure is finalized, constitutes the most common form of administration of perioperative intraperitoneal chemotherapy. Prognostic factors influencing survival in patients. Cytoreductive surgery crs with hyperthermic intraperitoneal chemotherapy hipec is used to treat peritoneal carcinomatosis, which often is secondary to gastrointestinal and ovarian cancers. Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy hipec has become the standard of care in the treatment of patients with peritoneal carcinomatosis ofcolorectal origin. Oxaliplatinbased versus irinotecanbased hyperthermic.
Hyperthermic intraperitoneal chemoperfusion is a new way to give chemotherapy. Jafari and colleagues aimed to determine the associated 30day morbidity and mortality of cytoreductive surgeryhyperthermic intraperitoneal chemotherapy hipec in the treatment of metastatic and primary peritoneal cancer in american college of surgeons national surgical quality improvement program. Crs combined with hyperthermic intraperitoneal chemotherapy hipec, median overall survival has signi. The objective was to examine the efficacy of laparoscopic hyperthermic intraperitoneal chemotherapy hipec in the palliation of refractory ma in patients who were unsuitable for cytoreductive surgery. Due to insufficient evidence of efficacy, intraoperative hyperthermic intraperitoneal chemotherapy hipec is unproven and not medically necessary for all other indications, including, but not limited to. The most effective treatment for patients with advanced disease is cytoreductive surgery followed by systemic chemotherapy. Hipec puts heated chemo drugs right into the abdomen. Pharmacology of cancer chemotherapy drugs for hyperthermic. Anaesthesia for cytoreductive surgery with hyperthermic.
The adoption of cytoreductive surgery crs with hyperthermic intraperitoneal chemotherapy hipec can. Cytoreductive surgery crs and hyperthermic intraperitoneal chemotherapy hipec provide an effective treatment option for selected patients with colorectal peritoneal metastasis with. Hyperthermic intraperitoneal chemotherapy hipec delivered in the operating room once the cytoreductive surgical procedure is finalized, constitutes the most common form of administration of perioperative intraperitoneal chemotherapy. Hyperthermia has direct cytotoxic effects on tumor cells and induces heat shock proteins that serve as receptors for natural killer cells. The majority of patients with ovarian cancer oc receive an initial diagnosis of advanced disease that has spread from the ovaries to the peritoneal surface. Complete cytoreduction may improve survival in highly selected patients low tumor volume and no organ metastases. Hyperthermic intraperitoneal chemotherapy with oxaliplatin. Tufts health plan covers hyperthermic intraperitoneal chemotherapy hipec when used as an adjunct to cytoreductive surgery for the following medical conditions. Hyperthermic intraperitoneal chemotherapy uchicago. November 20, 2019 prior authorization required if required, submit supporting clinical documentation pertinent to service request. This technique is common for peritoneal cancer that has spread from the.
Intraoperative hyperthermic intraperitoneal chemotherapy hipec page 2 of 14. Hyperthermic intraperitoneal chemotherapy early attempts at treatment for peritoneal carcinoma tosis with surgery alone produced rapid rates of pro gression and treatment failure. And there are also studies focus on treatment for it, such as parp inhibitors 23,24, hyperthermic intraperitoneal chemotherapy 25 and nanotherapy, but until now, survival rate of ovarian. Hyperthermic intraperitoneal chemotherapy hipec in ovarian cancer. Hyperthermic intraperitoneal chemotherapy hipec is a highly concentrated, heated chemotherapy treatment delivered directly to the abdomen during surgery. Cytoreductive surgery crs and hyperthermic intraperitoneal chemotherapy hipec provide an effective treatment option for selected patients with colorectal peritoneal metastasis with encouraging survival results. Hyperthermic intraperitoneal chemotherapy for ovarian cancer.
Hyperthermic intraperitoneal chemotherapy wikipedia. Hipec increases concentrations of chemotherapy directly within the peritoneal cavity compared with the intravenous route and reduces the. Intraoperative hyperthermic intraperitoneal chemotherapy. Hyperthermic intraperitoneal chemotherapy hipec is a potentially more attractive way to target microscopic peritoneal tumor deposits and is performed as a single procedure at the end of crs. In certain malignancies, it is associated with an improvement in the median 5year survival. Pdf hyperthermic intraperitoneal chemotherapy in ovarian cancer. Hyperthermic intraperitoneal chemotherapy hipec delivered in the operating room once the cytoreductive surgical procedure is finalized, constitutes the most common form of administration. Therefore, this study aims to assess the impact of hipec on patients with ovarian cancer.
Intraoperative hyperthermic intraperitoneal chemotherapy hipec page 1 of 14. Our data indicate that cytoreductive surgery and hyperthermic intraperitoneal chemotherapy is feasible and associated with a reasonable morbidity rate and mortality rate in. Intraoperative hyperthermic intraperitoneal chemotherapy hipec page 3 of unitedhealthcare oxford clinical policy effective 08012017 19962017, oxford health plans, llc intraperitoneal. In the setting of crs and hyperthermic intraperitoneal peroperative chemotherapy hipec, cisplatin has been used for intracavitary therapy of ovarian cancer in several phase ii studies37,38. The prognosis impact of hyperthermic intraperitoneal. Laparoscopic hyperthermic intraperitoneal chemotherapy hipec. Intraoperative hyperthermic intraperitoneal chemotherapy hipec page 2 of unitedhealthcare oxford clinical policy effective 08012017 19962017, oxford health plans, llc benefit. Hyperthermic intraperitoneal chemotherapy in ovarian. Hyperthermic or heated intraperitoneal chemotherapy hipec is a surgical procedure thats giving new hope to patients with abdominal cancers. Among patients with stage iii epithelial ovarian cancer, the addition of hipec to interval cytoreductive surgery resulted in longer recurrencefree survival and overall survival than surgery alone. Intraoperative hyperthermic intraperitoneal chemotherapy hipec. This may be complemented in some instances with early postoperative intraperitoneal chemotherapy epic.
Hyperthermic intraperitoneal chemotherapy hipec in conjunction with cytoreductive surgery crs holds promise as an adjunctive treatment strategy in malignancies affecting the peritoneal surface. In an attempt to improve the effectiveness of chemotherapy, an intraperitoneal hyperthermic approach has been proposed for the treatment of pc. Hyperthermic intraperitoneal chemotherapy for ovarian. Jun 28, 2004 our data indicate that cytoreductive surgery and hyperthermic intraperitoneal chemotherapy is feasible and associated with a reasonable morbidity rate and mortality rate in patients with peritoneal carcinomatosis and ovarian cancer. Importance hyperthermic intraperitoneal chemotherapy hipec and cytoreductive surgery have been shown to benefit selected patients with peritoneal carcinomatosis.
Hyperthermic intraoperative peritoneal chemotherapy hipec is also done for other cancers that have spread to the. For patients with certain advanced cancers that have spread to the lining of the abdomen, hipec can be a source for new hope. Mar, 2019 hyperthermic intraperitoneal chemotherapy is the administration of heated chemotherapy into the peritoneum after surgery. This is referred to as early postoperative intraperitoneal chemotherapy epic. Hyperthermic intraperitoneal chemotherapy hipec is a cancer treatment that involves filling the abdominal cavity with chemotherapy drugs that have been heated. Pdf hyperthermic intraperitoneal chemotherapy in ovarian.
We included comparative studies, and found that the overall survival os and progressionfree survival pfs in hipec groups were superior to groups without hipec treatment in the all total population hr 0. Final results of a phase iii randomized clinical trial xiaojun yang, md1, chaoqun huang, md1, tao suo, md2, liejun mei, md1, guoliang yang, md1. Hyperthermic intraperative peritoneal chemotherapy hipec. Intraperitoneal hyperthermic chemotherapy for abdominopelvic cancers page 2 of 8 the difference between traditional intraperitoneal chemotherapy and iphc is that in the traditional form, the chemolytic agents may be infused at the time of surgery or over a course of several days, however, these agents are not heated before being infused. Hyperthermic intraperitoneal chemotherapy hipec in.
Hyperthermic intraperitoneal chemotherapy hipec in conjunction with cytoreductive surgery crs holds promise as an adjunctive treatment strategy in malignancies affecting the peritoneal surface, effectively targeting remaining microscopic residual tumor. Hyperthermic intraperitoneal chemotherapy hipec, also referred to as intraperitoneal hyperthermic chemotherapy iphc, has been proposed as an alternative for the treatment of cancers within the. Hyperthermic intraperitoneal chemotherapy hipec in combined. Jan 18, 2018 hyperthermic intraperitoneal chemotherapy in ovarian cancer article pdf available in new england journal of medicine 3783. Following surgery to remove as much of the tumor as possible, a solution of heated chemotherapy drugs is pumped into the abdomen to target any cancer cells. Hyperthermic intraperitoneal chemotherapy hipec appendix.
Hyperthermic intraperitoneal chemotherapy an overview. It is usually performed following extensive cytoreductive surgery crs. The objective was to examine the efficacy of laparoscopic hyperthermic intraperitoneal chemotherapy hipec. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy improves survival of patients with peritoneal carcinomatosis from gastric cancer. Stephens ad, alderman r, chang d et al 1999 morbidity and mortality analysis of 200 treatments with cytoreductive surgery and hyperthermic intraoperative intraperitoneal chemotherapy using the coliseum technique. Intraperitoneal hyperthermic chemoperfusion hipec or iphc is a type of hyperthermia therapy used in combination with surgery in the treatment of advanced abdominal cancers.
Cytoreductive surgery with hyperthermic intraperitoneal. Hyperthermic intraperitoneal chemotherapy in ovarian cancer. Hyperthermic intraperitoneal chemotherapy in ovarian cancer article pdf available in new england journal of medicine 3783. Hyperthermic intraperitoneal chemotherapy the addition of hipec with cisplatin to cytoreductive surgery in stage iii ovarian cancer resulted in recurrencefree survival that was longer by 3. Hyperthermic intraperitoneal chemotherapy hipec is a treatment used immediately following cytoreductive surgery for treating some cancers that have spread into the peritoneal cavity. Hyperthermic intraperitoneal chemotherapy hipec is a technique which involves infusing chemotherapy heated to 428c438c into the peritoneal cavity. Hyperthermic intraperitoneal chemotherapy hipec delivered in the operating room once the cytoreductive surgical procedure is finalized, constitutes the most common form of administration of. Intraoperative hyperthermic intraperitoneal chemotherapy hipec page 4 of 14 unitedhealthcare commercial medical policy effective 06012019 proprietary information of unitedhealthcare. Such approach to treatment has already proved its efficiency in peritoneal carcinomatosis from colorectal cancer, peritoneal pseudomyxoma, and mesothelioma. Intraperitoneal hyperthermic chemotherapy for abdominopelvic cancers page 2 of 8 the difference between traditional intraperitoneal chemotherapy and iphc is that in the traditional form, the. Final results of a phase iii randomized clinical trial. What does hyperthermic intraperitoneal chemotherapy for. The crshipec procedure has become the standard of care in the treatment of patients with pc of colorectal origin 8.
551 1488 910 266 342 887 337 1571 1593 1625 1574 68 1151 688 722 1020 76 1517 995 229 1345 355 868 1258 1028 786 471 1005 1312 522 733